Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.

The majority of regulatory T cells (T(regs)) are believed to be of thymic origin. It has been hypothesized that this may result from unique intrathymic environmental cues, possibly requiring a dedicated antigen-presenting cell (APC). However, T cell-intrinsic developmental regulation of the susceptibility to T(reg) differentiation remains a mutually non-exclusive scenario. We found that upon ex...

Transcriptional control of regulatory T-cell differentiation.

Regulatory T (Treg) cells are essential for maintaining peripheral tolerance and for limiting excessive inflammatory responses under various conditions. The lineage-specific transcription factor Foxp3 has a critical role in Treg-cell biology. Foxp3 forms large protein complexes and cooperates with environmentally induced transcription factors to shape the Treg-cell transcriptional program. Here...

The Immunomodulatory Effect of Cyclophosphamide on Regulation of T-Cell Subsets and Antigen Presenting Cells.

The long-term maintenance of cytotoxic T cell memory does not require persistence of antigen

I have used the transfer of primed lymphocytes into syngeneic irradiated recipients to investigate whether the persistence of antigen is required in the long-term maintenance of cytolytic T cell memory to influenza virus. Animals were immunized with influenza virus (A/WSN) and used 17 wk later as either donors for T cells or as lethally irradiated recipients. Naive age-matched mice served as co...

Regulatory T-cell differentiation: Committed to control: a precocious choice?

The prevailing model of regulatory T (Treg) cell lineage commitment in the thymus entails that Treg cells differentiate from CD4+CD8+TCRab+double-positive (DP) precursors after T-cell receptor (TCR) engagement of major histocompatibility complex (MHC):peptide complexes. The discovery that Treg lineage commitment may occur at the earlier CD4 CD8 double-negative (DN) stage independently of cognat...